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  2. Depakote (divalproex sodium) affects chemicals in the body that may be involved in causing seizures. Depakote is used to treat various types of seizure disorders. This medicine is sometimes used together with other seizure medications. Depakote tablets and capsules are used to treat seizures in people with epilepsy who are at least 10 years old
  3. DEPAKOTE ® Sprinkle Capsules (divalproex sodium delayed release capsules), for oral use, is a prescription medicine used alone or with other medicines to treat: complex partial seizures in adults and children 10 years of age and older simple and complex absence seizures, with or without other seizure types IMPORTANT SAFETY INFORMATION 2-
  4. This medication is used to treat seizure disorders, certain psychiatric conditions (manic phase of bipolar disorder), and to prevent migraine headaches. It works by restoring the balance of certain..
  5. The medication Depakote (divalproex sodium) is an anticonvulsant. Doctors prescribe it to treat seizure disorders and to prevent migraine headaches. People also use it to manage the manic phase of bipolar disorder. Depakote side effects can be serious and sometimes fatal
  6. Valproate is a mood stabilizer medication that works in the brain. It is approved for the treatment of mania associated with bipolar disorder (also known as manic depression), seizures (epilepsy), and migraine headaches. Bipolar disorder involves episodes of depression and/or mania. Symptoms of depression include
  7. obutyric acid (GABA) in the brain. This medicine comes in different formulations, which are designed for specific..

Depakote is a prescription medicine used to treat the symptoms of mania, epilepsy, and migraine. Depakote may be used alone or with other medications. Depakote belongs to a class of drugs called Anticonvulsants, Other. It is not known if Depakote is safe and effective in children younger than 10 years of age Depakote is used in the treatment of seizure disorders, often in combination with other medications that can manage seizure disorders (Redirected from Depakote) Valproate (VPA) and its valproic acid, sodium valproate, and valproate semisodium forms are medications primarily used to treat epilepsy and bipolar disorder and prevent migraine headaches. They are useful for the prevention of seizures in those with absence seizures, partial seizures, and generalized seizures Depakote (divalproex sodium) is an antiepileptic drug used to treat seizure disorders, bipolar disorder and other neurologic conditions including migraine headaches. While many people may have benefitted from Depakote, others may have experienced severe or even life-threatening side effects

Depakote: Drug Uses, Dosage & Side Effects - Drugs

Depakote (divalproex sodium, sodium valproate, and valproic acid) is an anticonvulsant (anti-seizure) medication that is also used as a mood stabilizer in the treatment of bipolar disorder. Depakene contains the same medication—the difference is that Depakote is coated, which is thought to decrease some of the gastrointestinal side effect DEPAKOTE ® Sprinkle Capsules (divalproex sodium delayed release capsules), for oral use, is a prescription medicine used alone or with other medicines to treat: complex partial seizures in adults and children 10 years of age and older simple and complex absence seizures, with or without other seizure types IMPORTANT SAFETY INFORMATION 1- Depakene is a carboxylic acid with 8 carbons, a bunch of hydrogens, and two oxygens. Depakote is known generically as sodium divalproex, a term that should only be used when you want to appear.. When converting from divalproex delayed-release tablets (Depakote) to divalproex extended-release tablets (Depakote ER), administer the dosage of Depakote ER once daily at a dose 8% to 20% higher than the total daily dose of Depakote According to WebMd, Depakote is an oral medication that is used to treat some psychiatric conditions, such as the manic phase of bipolar; seizure disorders; and even as a migraine preventative.It restores balance to the neurotransmitters in the brain. You should take this medication as directed by your physician.If stomach upset occurs, you can take it with food

Epilepsy & acute bipolar mania treatment Depakote

Depakote Oral: Uses, Side Effects, Interactions, Pictures

An overdose of Depakote can cause problems with a person's heart. Depakote®, a brand for the drug valproic acid, is an anticonvulsant medication used to treat epilepsy, migraine headaches and the manic phase of bipolar disorder.It regulates neurotransmitter activity in the brain to prevent the brain's electrical system from misfiring Depakote is a serious medication that shouldn't be touched without a prescription. It's usually the last form of treatment for patients with bi polar disorder after all other meds (lamictal, lithium etc) didn't work. Although it is thought to work on the GABA receptors, the mechanism of action is relatively unknown, so this leads me to believe. Valproate (valproic acid; divalproex sodium, a compound containing sodium valproate and valproic acid) controls absence, myoclonic, and tonic-clonic seizures in generalized, idiopathic, and symptomatic epilepsy. It is most useful in typical absence seizures. Valproate is as effective as ethosuximide in patients with absence seizures alone and. Depakote: Initiation: Check baseline labs (urine pregnancy, platelet counts, coagulation tests, and liver function tests). Week 1: Start Depakote ER (extended-release) 750 mg QHS. Week 2: Check trough Depakote ER plasma level before, but as close to the dosing time as possible. If level is sub therapeutic, add 250-500 mg to QHS dose. Repeat weekly as need to reach therapeutic dosage Divalproex sodium is a mixture of two similar ingredients - valproic acid and sodium valproate. It is an anticonvulsant medicine used to treat bipolar disorder, epilepsy and seizures, and to prevent migraine headaches. A seizure is a short episode of symptoms which is caused by a burst of abnormal electrical activity in the brain

Algorithm for Treating Epilepsy Patients with Valproate (Depakote, valproic acid)* Patient presents with Seizures or unacceptable side effects Diagnose Partial or Primary Generalized Epilepsy (simple partial, complex partial, primary or secondarily generalized tonic clonic, absence, juvenile myoclonic, atonic, etc Divalproex (Depakote) is a moderately priced drug used to prevent seizures caused by some forms of epilepsy.It is also used to treat bipolar mania and to prevent migraine headaches. This drug is slightly less popular than other comparable drugs. It is available in brand and generic versions Depakote® (divalproex sodium) tablets Depakote® ER (divalproex sodium) extended-release tablets Please note: This program is available for people diagnosed with a seizure disorder and for re-enrollment of patients previously approved for assistance. myAbbVie Assist provides free medicines to qualifying patients Divalproex (Depakote) Safety. Side Effects. Warnings. Contraindications. Drug Interactions. Dosage. Divalproex (Depakote) is an anti-seizure drug that has been used for almost fifty years. It is also used to manage bipolar disorder, epilepsy, and migraines. But it can cause a number of side effects ranging from nausea to liver damage

Overview. Depakote (Valproic Acid) is a drug used for the treatment of petit mal, grand mal, mixed and akinetic-myoclonic seizures. Valproic acid is a prescription medication that has been proven effective in the treatment of epilepsy, chronic migraine headaches, and manic episodes associated with bipolar disorder, also known as manic depression Depakote has been on the market for more than 30 years, and some side effects from long-term use are becoming apparent. More than six months is considered long-term use. Blood Clotting. The most well-known long-term side effect is the blood having more of a tendency to clot. Blood clots can lead to stroke or a heart attack Depakote (divalproex) Prescription only. 46% of people say it's worth it. 3 dosage forms. $15.62 is the lowest price near you. Want to save even more money Depakote 500 Tablet is a medicine used to treat epilepsy. It helps prevent and control seizures (fits). It is also used in the prevention of migraines. Occasionally, it may also be used to treat bipolar disorder. Depakote 500 Tablet may be used alone or in combination with other medicines

Depakote - What is Depakote & What is It Used For

Descriptions. Valproic acid is used to treat certain types of seizures (epilepsy). This medicine is an anticonvulsant that works in the brain tissue to stop seizures. Valproic acid is also used to treat the manic phase of bipolar disorder (manic-depressive illness), and helps prevent migraine headaches. This medicine is available only with your. Depakote (Generic Name: divalproex sodium) is an anticonvulsant medication prescribed to treat manic episodes associated with bipolar disorder; alone or in tandem with other medications to prevent and control seizures in patients age 10 and older; and to prevent migraine headaches. It treats complex partial onset seizures that occur on their. Depakote is an anticonvulsant drug manufactured and marketed by Abbott Laboratories. This drug has been used for nearly 25 years to treat individuals suffering from epilepsy, manic bipolar behavior, and migraines. In recent years, however, class action lawsuits have been filed against Abbott Laboratories after evidence surfaced that Depakote.

Valproate (Depakote) NAMI: National Alliance on Mental

Depakote is the brand name for the drug divalproex sodium. It is a type of mood stabilizer made up of sodium valproate and valproic acid, according to RXList. 1 It comes in three different forms, including Depakote, Depakote ER (extended release), and Depakote Sprinkle Capsules (delayed release). Sodium valproate was first discovered 2 back in 1881, but its medicinal benefits were not. Depakote comes in different dosage forms with different usages. Depakote Tablets and Depakote Extended-Release Tablets are prescription medicines used: • to treat manic episodes associated with bipolar disorder • alone or with other medicines to treat: complex partial seizures in adults and children 10 years of age and olde

Depakote (Divalproex Sodium) - Side Effects, Interactions

Depakote Side Effects. Side effects of Depakote and Depakote ER can be serious and sometimes deadly. Depakote side effects include liver damage, life-threatening pancreatitis, suicidal thoughts, and blood and metabolic disorders. When women take Depakote during pregnancy, their children have a higher risk of birth defects. By Elaine Silvestrini Depakote class. Depakote indications. Depakote actions. 125 mg 1 tablet by mouth at bedtime. ~anticonvulsant, vascular headache suppressant. ~complex absence seizures, complex partial sezures, absense se. ~increase GABA levels, an inhibitory neurotransmitter in the C. Depakote patient dose. 125 mg 1 tablet by mouth at bedtime Insomnia is a potential side effect of Depakote. This article from the eMedTV archives offers more information on Depakote and insomnia, including a definition of what insomnia is and a list of tips for improving your sleep habits 1. Name of the medicinal product. Depakote 250 mg Tablets. 2. Qualitative and quantitative composition. Containing 269.10 mg of valproate semisodium* per tablet (equivalent to 250 mg of valproic acid). *Valproate semisodium is a stable coordination compound comprised of sodium valproate and valproic acid in a 1:1 molar relationship Depakote is a medication used to treat seizures, psychiatric disorders, and severe migraines. Designed to restore the balance of natural chemicals in the brain called neurotransmitters, Depakote is manufactured by Abbott Laboratories as a brand name version of the generic drugs divalproex sodium and valproic acid

Depakote (Depakote Divalproex Sodium Tablets): Uses

  1. This pilot study evaluates the safety and efficacy of divalproex sodium (Depakote) for alcohol withdrawal and relapse prevention. Sixteen patients in moderate alcohol withdrawal were randomized to receive a standard benzodiazepine detoxification, depakote detoxification, or depakote detox plus maintenance
  2. This is effective for many patients. However, higher doses of Depakote® are commonly used. In migraine prevention, doses of 750 to 1500 mg per day are optimal for many patients. The dose can be divided with the standard direct release tablet or given as a bedtime only dose when used at doses of 1000 mg or less. This may reduce side effects
  3. Valproic acid is used alone or with other medications to treat certain types of seizures. Valproic acid is also used to treat mania (episodes of frenzied, abnormally excited mood) in people with bipolar disorder (manic-depressive disorder; a disease that causes episodes of depression, episodes of mania, and other abnormal moods)
  4. obutyric acid in the brain.GABA is a natural brain chemical that stops or slows down other brain signals. Increasing GABA helps to prevent the abnormal brain signals that lead to a seizure.It is also thought that Depakote may prevent seizures by affecting sodium channels in the brain
  5. {{configCtrl2.info.metaDescription}} and discontinuing valproate at the same time that lithium is started and titrated up.Valproate is generally tapered over one week by the same amount for each dose decrease (eg, valproate 2000 mg per day
  6. Depakote ER is an extended release pill, meaning you should only have to take it once a day, versus, Depakote DR which is delayed release and taken multiple times a day. Delayed release is a coated pill that all medication is released when the coating dissolves. The coating helps reduce upset stomach that can b

Depakote x USW. Depakote USW. The Gummo Album. i LIVE TO DIE AND I DIE TO LIVE. Suicide Watch. SideTracked. Random. Creative FreeDumb. Do What I want Depakote, Neurontin and Lyrica for Anxiety; Back to Free Help. Valproic Acid (Depakote) Possible Benefits. Valproic acid is an epilepsy medication that is now used for the treatment of panic attacks as well as other psychiatric problems. May work better by adding it to a primary medication that is not completely effective Depakote can cause liver failure that may be fatal, especially in children under age 2. This risk may be greater in children taking more than one seizure medication, or those who have a metabolic disorder or brain disease causing mental impairment. You should not use Depakote if you are allergic to divalproex sodium, or if you have: liver. Divalproex sodium (Depakote). This is a parallel groups design lasting a total of six weeks. Participants will be on a fixed-flexible dosing schedule. The dose of depakote will be raised to 750mgs or 1000mgs, depending on weight, in two weeks to achieve blood levels between 50-130 micrograms per milliliter The use of valproic acid (VPA) (also known as Depakote, Depakene, and others) frequently results in elevated plasma ammonia. In some people, hyperammonemia may be clinically significant, resulting in hyperammonemic encephalopathy, which may be severe. Valproic acid-induced hyperammonemic encephalopa

Depakote Withdrawal Help Valproic Acid Side Effects

Generic Name Divalproex Trade Name Depakote Indication Seizures, manic episodes, prevention of headache Action Increases the level of GABA (inhibitory neurotransmitter) in CNS Therapeutic Class Anticonvulsant, vascular headache suppressants Pharmacologic Class None Nursing Considerations • May cause suicidal thoughts, agitation, dizziness, insomnia, hepatotoxicity, pancreatitis • Increases. 070789. Order Code Name. Free Valproic Acid (Depakote) Order Loinc. 4087-3. Result Code. 070790. Result Code Name. Free Valproic Acid (Depakote

Valproate - Wikipedi

Depakote has since become the most-prescribed drug (surpassing lithium) for treating manic episodes associated with bipolar disorder, also known as manic depression. Lithium was the only FDA. dizziness. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position. dry mouth. excessive muscle tone. fast, irregular, pounding, or racing heartbeat or pulse. feeling of warmth or heat. flushing or redness of the skin, especially on the face and neck. frequent urge to urinate Adult: PO 250 mg b.i.d. (max: 1000 mg/d) or Depakote ER 500 mg q.d. x 1 wk, may increase to 1000 mg q.d. Mania Adult: PO 250 mg t.i.d. (max: 60 mg/kg/d) Administration Oral. Give tablets and capsules whole; instruct patient to swallow whole & not to chew. Instruct to swallow sprinkle capsules whole or sprinkle entire contents on teaspoonful of. Depakote —> can result in biotin deficiency and low biotinidase enzyme activity —> results in alopecia (hair loss). Additional role of low zinc level with long term depakote treatment. The following study supports this underlying mechanism: 32 pediatric patients (22 females, 10 males) receiving valproate treatment

I love depakote! It knocks out my manic episodes in days. I am also on 1500mgs for maintenance, along with lithium and seroquel. The only problem for me has been weight gain. I can say for certain that the depakote caused the weight gain, as I have taken it before and the same thing happened So we all learn in school that Depakote can cause elevated LFTs. Had an interesting patient we were trying to determine if her LFT abnormality was from Depakote versus underlying liver disease: 1. What is the typical extent of the LFT increase (how high do AST and ALT rise) when on Depakote.. How well has Depakote helped with anger outbursts for any of you here who take it. I just got taken off of Abilify and put on Depakote ER. I'm on medical leave from work right now - I felt like exploding while there. So I'm hoping that Depakote will help me to prevent myself from having.. The Related Drug Information Index provides comprehensive access to all drug information related to a specific drug Types of content include full prescribing information, drug summaries, Full Prescribing Information Continuing Medication Education (Full PI CME), Medication Guides, Risk Evaluation and Mitigation Strategies (REMS Summaries), REMS Continuing Medication Education (REMS CME), and. Depakote (Valproic acid) is a compound that is utilized as an anticonvulsant to help prevent seizures in epileptics. It also has mood stabilizing properties and is approved to help treat and prevent mania among individuals with bipolar disorder

Depakote Side Effects - FDA Warning, Organ Damage & Lawsuit

Depakote (Divalproex sodium) for Autism. Depakote is a prescription drug that was first approved by the Food and Drug Administration (FDA) in 1983 to treat epilepsy. It is also approved to treat manic episodes in people with bipolar disorder. In children with autism spectrum disorders (ASD), Depakote can be effective in addressing impulsive. What is divalproex?. Divalproex is an anticonvulsant medication that is used to manage certain types of epilepsy, migraine disorders, and bipolar mood disorder which is a mental health condition associated with alternating phases of mania and depression A 43-year-old man with epilepsy who had been treated with valproic acid (Depakote®) (VPA) 2 for 13 years and had a history of multiple suicide attempts and alcohol dependence presented after ingesting an overdose of VPA and ibuprofen. The patient was not on any other prescribed medications This article takes a systematic look at the literature regarding the efficacy of using valproic acid (Depakote) as an adjunctive (additional to an antipsychotic) medication for schizophrenia. This medicine is a mood stabilizer and is typically a first line drug for treating bipolar disorder Depakote (divalproex sodium) Extended Release Tablets - Prescribing and Labeling Information Depakene (valproic acid) - Prescribing and Labeling Information Content current as of

Depakote (divalproex) is a first-line treatment to stabilize mood for people with bipolar disorder. Depakote (divalproex) is helpful for preventing frequent migraines. The sprinkle pill can be swallowed whole or can be opened up and mixed with applesauce if you have a hard time swallowing. Depakote (divalproex) is available as a generic Depakote EC vs Depakote SA . Note in graphic Divalproex ER is the same as Divalproex SA in the text . Reed and colleagues conducted a computer simulation of conversion for divalproex EC to SA. 12 . The four possible divalproex q12h to once-daily divalproex ER formulation conversion strategies selected for study were th Depakote also blocks voltage-dependent sodium channels, which results in suppression of high-frequency repetitive neuronal firing (i.e. the reason it is successful as an anti-epileptic). It is a drug with three major FDA approvals (as above) and it has recognized off-label uses: bipolar major depression, maintenance treatment of bipolar. Depakote can be very sedating when someone first starts it, as Reverseroles noted was her mother's experience. Since it calms the brain, as Reverseroles also noted, the staring and confusion can also happen when first started, until the brain adapts. Often this will wear off over time and/or a dose reduction

VALPROATES divalproex sodium (dye-val-proe-ex soe-dee-um). Apo-Divalproex, Depakote, Depakote ER, DOM-Divalproex, Epival, Gen-Divalproex, Novo-Divalproex, Nu-Divalproex, PHL-Divalproex, PMS-Divalproex valproate sodium (val-proe-ate soe-dee-um). Depacon. valproic acid (val-proe-ik as-id). Apo-Valproic, Depakene, DOM-Valproic Acid, PHL-Valproic Acid, PMS-Valproic Acid, Ratio-Valprox, Stavzo Depakote ER (divalproex sodium) extended-release tablets Indication 1- acute treatment of manic or mixed episodes associated with bipolar disorder, with or without psychotic features. Approved in 2000. Dosing/Administration. Depakote ER is an extended-release product intended for once-a-day oral administration

Depakote (divalproex sodium) is a medication regularly prescribed for the management of epilepsy, bipolar disorder, and migraine headaches. Other medical conditions for which Depakote is occasionally utilized as a complementary (i.e. adjunct) therapy include: AIDS, cancer, dopamine dysregulation syndrome (associated with Parkinson's disease), schizophrenia Depakote has been the ONLY med I have been able to succesfully take for my BP..everything else was a disaster. JasmineRenee 05/20/2010. I take the same, weight gain and a tad bit of dizziness is all I am a dealing with. It works pretty well, just don't forget to get your levels checked every so often. It's not a lot for this med : Commonly used drugs: Valproic acid (brand name Depakote) is the most commonly used medication of this type, in older adults with dementia. It is available in short- and long-acting formulations. Usual effects: The effect varies depending on the dose and the individual. It can be sedating Depakote, Depacote ER: Prophylaxis of migraine headaches Divalproex, sodium valproate injection: Treatment of complex partial seizures as monotherapy or with other antiepileptics Unlabeled uses: Adjunct in symptom management of schizophrenia, treatment of aggressive outbursts in children with attention-deficit hyperactivity disorder, organic.

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Common and Rare Side Effects for Depakote ora

  1. e, Remeron, Risperidone, Zopiclone & Cannabis: Medications Didn't Really Affect Other Drugs: bigck: Divalproex, Venlafaxine, Aripiprazole & Others: Experience Reports are the writings and opinions of the individual authors who submit them
  2. Depakote Lawsuit Information. Depakote (divalproex sodium) is a popular antiepileptic drug. The medication is also prescribed for the prevention of migraines and for the treatment of bipolar disorder's manic phases. Although Depakote isn't a selective serotonin reuptake inhibitor (SSRI), doctors sometimes prescribe the drug in conjunction with.
  3. Regardless of the formulation used (divalproex sodium (as 1:1 sodium valproate:valproic acid; Depakote) or valproic acid only (Depakene)), the active form in the body is valproate and is approved as monotherapy and adjunctive therapy in complex partial seizures and pediatric patients (>10 years of age)
  4. Depakote is actually a brand name used in countries such as the United States and the United Kingdom. Other brand names include Epival and Valance. Other brand names include Epival and Valance. The drug is actually called valproate semisodium or divalproex sodium , and is a compound of sodium valproate and valproic acid

Depakote is a CNS-acting drug usually prescribed for migraines, seizures and bipolar disorder. Because it can react negatively with alcohol, users should be made aware of this interaction. Signs of Depakote and Alcohol Interactio Oral: Depakote Stavzor 750mg/d or Depakote ER 25mg/kg/d qday; Migraine prophlyaxis. Oral: Depakote, Stavzor 250mg BID or Depakote ER 500mg qday; Pediatric Dosing. Same as adult dosing; Avoid extended release formulation in children <10yr; Special Populations. Pregnancy Rating: X; Lactation: Use with caution. Excreted in breast milk. Renal. Adult Dosing . Dosage forms: DR TAB: 125 mg, 250 mg, 500 mg partial seizures, complex [30-60 mg/kg/day PO divided bid-tid] Start: 10-15 mg/kg/day PO divided qd-tid, incr. by 5-10 mg/kg/day q7 days; Max: 60 mg/kg/day; Info: decr. start dose and titrate slowly in elderly pts; adjust dose based on tx response and serum levels; divide doses >250 mg/day; give w/ food; taper dose gradually to D/

How to say depakote in English? Pronunciation of depakote with 3 audio pronunciations, 1 meaning, 3 translations and more for depakote Since Depakote has been used to treat seizures in children for more than twenty years, a great deal was known about its safety profile in the pediatric population. The investigators treated 7 children, age 7-12, whose recurrent temper outbursts and chronic mood lability did not respond to individual/family therapy

Depakote for Bipolar Disorder: Facts, Side Effects, Cost

Depakote is a prescription medication that is used to treat epilepsy, manic depression/bipolar disorder and migraines. It is usually taken orally in the form of either delayed-release tablets or as sprinkle capsules which can be added to soft foods and swallowed Depakote blood levels are important. Laboratories typically define therapeutic Depakote levels as between 50 and 100 ng/dl, and will flag a level above 100 as potentially toxic. That said, those of us who treat a lot of bipolar patients sometimes find that we need blood levels in the 100 to 120 ng/dl range. In most people this is well-tolerated

Side Effects of Depakote (Depakote Divalproex Sodium

Depakote. The Food and Drug Administration approves Depakote, also known as divalproex sodium or valproic acid, for treating mania in bipolar disorder. According to the National Alliance on Mental Illness, depakote, which is an anti-convulsant drug, is more commonly prescribed than the mood-stabilizer Lithium for the treatment of mania Valproic acid is a prescription medicine. It's important to take it as advised by your doctor. Dosage. The usual dose for treating: bipolar disorder in adults: the usual dose is 750mg to 2,000mg a day, split into 2 or 3 doses; bipolar disorder in children: the doctor will work out the right dose for your child; migraine in adults: daily doses vary from a single dose of 400mg to 1,500mg split.

To the Editor: Thrombocytopenia is a condition in which the blood has a lower than the normal platelet count. Thrombocytopenia is derived from the old term thrombocytes, ie, cells responsible for blood clotting or thrombus. 1 Bone marrow produces platelets along with other kinds of blood cells. Normal platelet count is between 150,000 and 450,000/μL of blood Depakote destroyed my physical health. Inability to concentrate even for a minute, dizziness, lack of motivation, tiredness throughout the whole day, depression, migraines, stomach aches, hand tremors, weird dreams, mood swings, anger issues, body temperature issues, social withdrawral, comprehension issues Depakote ER: 500 mg PO qDay for 7 days; based on patient response, may increase and adjust dose to 500-1000 mg/day. Bipolar Mania. Indicated for treatment of manic episodes associated with bipolar disorder. Stavzor: 750 mg/day PO in divided doses; adjust dose as rapidly as possible to desired therapeutic effect; not to exceed 60 mg/kg/da

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