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Oxymetazoline ptosis

Super Angebote für Voltaflex Glucosaminhydrochlor 4 2 hier im Preisvergleich. Große Auswahl an Voltaflex Glucosaminhydrochlor 4 2 In their studies of oxymetazoline hydrogen chloride (HCl), 0.1%, Slonim et al 1 randomized a total of 304 patients with acquired ptosis to topical oxymetazoline HCl, 0.1%, vs vehicle in 2 trials. These are industry-sponsored trials for which the authors report that RevitaLid Inc played a role in the conduct, analysis, and reporting of the studies Oxymetazoline for Ptosis. Oxymetazoline for Ptosis. Oxymetazoline for Ptosis JAMA Ophthalmol. 2020 Nov 1;138(11):1176-1177. doi: 10.1001/jamaophthalmol.2020.3833. Authors Elizabeth A Bradley 1 , David J Bradley 2 Affiliations 1 Mayo Clinic Department of Ophthalmology, Mayo. Oxymetazoline, 0.1%, was associated with positive outcomes and was well tolerated in phase 3 trials after instillation at days 1 and 14, demonstrating its potential promise for the treatment of acquired ptosis, although further study is needed to elucidate the clinical relevance of these findings be

Oxymetazoline hydrochloride 0.1%, a preservative-free eye drop, was well tolerated and produced positive outcomes in the treatment of acquired ptosis, according to a study Oxymetazoline hydrochloride 0.1% helps fill unmet need for patients with ptosis By Derek N. Cunningham, OD Although mild to moderate ptosis is common, affecting about 12% of the population older than 50,1,2 many eye care specialists are hesitant to engage these patients

Oxymetazoline hydrochloride, 0.1%, ophthalmic solution (oxymetazoline, 0.1%; RVL Pharmaceuticals Inc) is a novel pharmacologic agent approved for the treatment of acquired ptosis. Oxymetazoline is a potent, direct-acting α-adrenergic receptor agonist that binds the α 1 and α 2 subtypes. 28,29 It is used, at low concentrations, as a topical. USA: Oxymetazoline, 0.1% may be a promising treatment for acquired ptosis, suggest a recent study in the journal JAMA Ophthalmology. This will do away with the need to undergo surgery for treating the condition. Blepharoptosis (or ptosis) is drooping down of the upper eyelid margin with the eye in primary gaze Upneeq (oxymetazoline hydrochloride ophthalmic solution, 0.1%) is a once-daily ophthalmic formulation of the direct-acting alpha-adrenergic receptor agonist oxymetazoline indicated for the treatment of acquired blepharoptosis, or ptosis, a condition characterized by the abnormal drooping of the upper eyelid. its novel treatment for acquired. UPNEEQ®(oxymetazoline hydrochloride ophthalmic solution), 0.1% is a prescription eyedrop used to treat acquired blepharoptosis (low-lying lids) in adults. What warnings and precautions are associated with UPNEEQ

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  1. ODs can consider one of three medical treatments for ptosis: apraclonidine ophthalmic drops, botulinum toxin injection and oxymetazoline
  2. Although surgery has been the mainstay of ptosis treatment to date, there is now a new option: preservative-free oxymetazoline HCl ophthalmic solution 0.1% (Upneeq, RVL Pharmaceuticals), which was approved by the FDA last year for the treatment of acquired blepharoptosis
  3. Oxymetazoline hydrochloride, 0.1%, ophthalmic solution is approved for the treatment of acquired ptosis and is thought to stimulate receptors on the Müller muscle, causing the contraction and..
  4. istered to the eye, is believed to selectively target the Müller muscle and elevate the upper eyelid
  5. Upneeq is a prescription version of oxymetazoline ophthalmic that is used to treat blepharoptosis, a condition that causes a droopy eyelid over one or both eyes. Upneeq is for use in adults and children at least 13 years old. Oxymetazoline ophthalmic may also be used for purposes not listed in this medication guide
  6. Oxymetazoline hydrochloride, 0.1%, ophthalmic solution is a novel pharmacologic agent approved for the treatment of acquired ptosis. Oxymetazoline is a potent, direct-acting α-adrenergic receptor agonist that binds the α1 and α2 subtypes
  7. istered to the eye, is believed to stimulate Müller muscle causing contraction resulting in elevation of the upper eyelid, said Tina deVries, PhD, Executive Vice President, Research & Development, Osmotica

Oxymetazoline for Ptosis External Eye Disease JAMA

Upneeq contains oxymetazoline, an alpha adrenergic agonist that triggers the levator palpebrae muscle (Muller's or Mueller's muscle), causing the muscle to contract and raise the upper eyelid. Upneeq works by stimulating an involuntary eyelid muscle, the Muller's muscle, to contract Acquired ptosis (low-lying lids) is a common medical condition that: Can develop later in life ; Affects adults of all ages, but occurs more often with increased age UPNEEQ ® (oxymetazoline hydrochloride ophthalmic solution), 0.1% is a prescription eyedrop used to treat acquired blepharoptosis (low-lying lids) in adults A daily drop of oxymetazoline ophthalmic solution demonstrated sufficient improvement in the visual impairment and cosmetic appearance of acquired ptosis for some patients to avoid corrective surgery, in a recently published analysis of data from two phase 3 trials which were pivotal for US Food and Drug Association (FDA) approval of the agent (Upneeq) in July Oxymetazoline, 0.1% improves vision outcomes in ptosis patients Treating patients with blepharoptosis — the drooping of the upper eyelid, also known as ptosis — with oxymetazoline, 0.1%, led to improved vision outcomes and was well tolerated, according to results from two randomized clinical trials Upneeq (oxymetazoline hydrochloride ophthalmic solution), 0.1%, equivalent to 0.09% as oxymetazoline base, is formulated for topical ocular delivery as a sterile, non-preserved, clear, colorless to slightly yellow ophthalmic solution. Contraindications. None. Warnings and Precautions Ptosis as Presenting Sign of Serious Neurologic Diseas

JAMA Ophthalmology Publishes Pooled Analysis of Data from two Phase 3 Clinical Trials of Upneeq™ (oxymetazoline hydrochloride, 0.1% solution) for Acquired Ptosis - read this article along with other careers information, tips and advice on BioSpac Upneeq™ (oxymetazoline hydrochloride) 0.1% is a once-daily ophthalmic solution that is shown to provide a visible lift to a droopy eyelid in just 5-15 minutes. The lift can last up to 6 hours, making the drops a highly effective method of relief for ptosis

The Food and Drug Administration (FDA) has approved Upneeq™ (oxymetazoline hydrochloride ophthalmic solution; Osmotica) for the treatment of acquired blepharoptosis in adults UPNEEQ (oxymetazoline hydrochloride ophthalmic solution), 0.1% is an aseptically prepared, sterile, non-preserved, clear, colorless to slightly yellow ophthalmic solution; 0.3 mL fill in a clear... 17 PATIENT COUNSELING INFORMATION Advise the patient and/or caregiver to read the FDA-approved patient labeling (Instructions for Use)

Ptosis is an abnormal drooping of the upper eyelid margin with the eye in primary gaze1. 97.5% of participants receiving oxymetazoline 0.1% and 97.0% of participants receiving vehicle. A new prescription eye drop for Ptosis can make eyes look dramatically more awake. oxymetazoline—the same drug in the original formula of Visine and still found in Afrin nasal spray—which. Specifically, the Phase 3 trials are for RVL (oxymetazoline hydrochloride ophthalmic solution, 0.1%) for the treatment of ptosis. Drooping or falling of the upper eyelid due to ptosis may be.

Schematic presentation of oxymetazoline effects on the

(oxymetazoline hydrochloride ophthalmic solution), 0.1% The only FDA-approved prescription eyedrop for acquired ptosis (low-lying lids) that lifts your upper eyelids to open your eyes IMPORTANT SAFETY INFORMATION What is UPNEEQ? UPNEEQ® (oxymetazoline hydrochloride ophthalmic solution), 0.1% is a prescription eyedrop used to trea Ptosis is defined as abnormal drooping of either right and/or left upper eyelid that usually occurs from a partial or complete dysfunction of the muscles that elevate the upper eyelid - the levator palpebrae and the Müller's muscle. The first-in-class treatment called RVL-1201 is an ophthalmic formulation of oxymetazoline, a direct. It's called ptosis, and it's an issue that affects millions of people in the U.S. alone: The eye drop contains 0.1 percent of an active ingredient called oxymetazoline hydrochloride, which. If ptosis is present but not causing any functional problems, a person may not need any treatment at all. Daily doses of the medication oxymetazoline can affect the levator muscle

An eyedrop called Upneeq is the first drug approved by the United States Food and Drug Administration to treat acquired ptosis, a condition where the upper eyelid droops over the eye. An estimated 11.5% of adults have droopy eyelid, but many don't know it's considered a disorder — or that it can be treated.. Droopy eyelid occurs when muscles that keep the eye open lose function with age UPNEEQ ® (oxymetazoline hydrochloride ophthalmic solution), Ptosis may be associated with neurologic or orbital diseases such as stroke and/or cerebral aneurysm, Horner syndrome, myasthenia gravis, external ophthalmoplegia, orbital infection and orbital masses. Consideration should be given to these conditions in the presence of ptosis.

Oxymetazoline for Ptosis - PubMe

  1. e the efficacy and safety of oxymetazoline hydrochloride, 0.1%.
  2. Conclusions and Relevance Oxymetazoline, 0.1%, was associated with positive outcomes and was well tolerated in phase 3 trials after instillation at days 1 and 14, demonstrating its potential promise for the treatment of acquired ptosis, although further study is needed to elucidate the clinical relevance of these findings beyond 6 weeks
  3. Oxymetazoline is an alpha adrenoceptor agonist believed to target Mueller's muscle, which raises the upper eyelid. Until now, ptosis patients have had two treatment options: surgery or off-label.
  4. The U.S. FDA has approved Upneeq™ (oxymetazoline hydrochloride ophthalmic solution 0.1%), manufacture by Osmotica Pharmaceuticals, to treat acquired blepharoptosis in adults. It is the first FDA-approved medication for this condition. Blepharoptosis is also known as ptosis. The condition is characterized by an abnormally low-lying or drooping upper eyelid, which ca
  5. Oxymetazoline (Upneeq™) is Blepharoptosis, also known as ptosis, is an abnormal low-lying upper eyelid margin, which can decrease or even completely occlude vision.2 Two vehicle-controlled pivotal studies were conducted; results are not published a
  6. INDICATION UPNEEQ ® (oxymetazoline hydrochloride ophthalmic solution), 0.1% is indicated for the treatment of acquired blepharoptosis in adults. IMPORTANT SAFETY INFORMATION WARNINGS AND PRECAUTIONS. Ptosis may be associated with neurologic or orbital diseases such as stroke and/or cerebral aneurysm, Horner syndrome, myasthenia gravis, external ophthalmoplegia, orbital infection and orbital.
  7. RVL Pharmaceuticals, a subsidiary of Osmotica Pharmaceuticals, announced that its ptosis drug Upneeq (oxymetazoline hydrochloride ophthalmic solution), 0.1% has been selected as the winner of the Best New Technology Solution for Drug Delivery award in the fifth annual MedTech Breakthrough Awards program conducted by MedTech Breakthrough, an independent market intelligence organization.

Association of Oxymetazoline Hydrochloride, 0

Oxymetazoline is a member of the class of phenols that is 2,4-dimethylphenol which is substituted at positions 3 and 6 by 4,5-dihydro-1H-imidazol-2-ylmethyl and tert-butyl groups, respectively. A direct-acting sympathomimetic with marked alpha-adrenergic activity, it is a vasoconstrictor that is used (generally as the hydrochloride salt) to relieve nasal congestion FDA Approves Upneeq (oxymetazoline hydrochloride ophthalmic solution) for Acquired Blepharoptosis (Droopy Eyelid) in Adults Print this page BRIDGEWATER, N.J, July 09, 2020 (GLOBE NEWSWIRE) — Osmotica Pharmaceuticals plc (Nasdaq: OSMT) (Osmotica or the Company), a fully integrated biopharmaceutical company, announced today that the U.S. Food and Drug Administration (FDA) has. Ptosis may be associated with neurologic or orbital diseases such as stroke and/or cerebral aneurysm, Horner syndrome, myasthenia gravis, external ophthalmoplegia, orbital infection and orbital masses. Oxymetazoline hydrochloride did not cause adverse effects to the fetus at oral doses up to 0.2 mg/kg/day in pregnant rats during the period. Class Summary. The FDA approved oxymetazoline ophthalmic solution in July 2020 for the treatment of acquired blepharoptosis in adults. Oxymetazoline ophthalmic (Upneeq) View full drug information. Indicated for acquired blepharoptosis in adults. Previous. References. Collin JRO. Ptosis

Views 7717. The FDA has cleared a novel ophthalmic solution of oxymetazoline hydrochloride (Upneeq) for acquired blepharoptosis, making it the only approved therapy for the condition. According to Osmotica Pharmaceuticals, once-daily application of the drug—a direct-acting alpha adrenergic receptor agonist—elevates the upper eyelid by. Ptosis As Presenting Sign Of Serious Neurologic Disease. Oxymetazoline hydrochloride was not associated with an increased incidence of neoplastic or proliferative changes in transgenic mice given oral doses of 0.5, 1.0, or 2.5 mg/kg/day oxymetazoline hydrochloride for 6 months Acquired ptosis, or low-lying lids, is a common condition that impacts millions of adults in their 40s and 50s, and sometimes younger individuals as well. Over time, the eyelid muscles stretch or weaken, which causes the upper eyelid to droop. Oxymetazoline functions as a decongestant in Afrin nasal spray and was once used in Visine at a. • The Phase 3 clinical trials of Upneeq excluded patients with congential ptosis and mechanical ptosis (e.g., ptosis due to excess weight on the upper lid possibly from infections, inflammation, and eyelid tumors) Conclusions and Relevance: Oxymetazoline, 0.1%, was associated with positive outcomes and was well tolerated in phase 3 trials after instillation at days 1 and 14, demonstrating its potential promise for the treatment of acquired ptosis, although further study is needed to elucidate the clinical relevance of these findings beyond 6 weeks

Oxymetazoline hydrochloride 0

Oxymetazoline eye drops, a promising treatment for ptosis

Upneeq Eye Drops To Treat Acquired Ptosis (Droopy eyelid

  1. istration to an eye. In one embodiment the composition includes a synergistic combination of oxymetazoline and phenylephrine, formulated for topical ad
  2. Oxymetazoline functions as a decongestant in Afrin nasal spray and was once used in Visine at a lower concentration. During clinical trials, Upneeq® aimed to improve a patient's vision by stimulating the alpha-adrenergic receptors in the eye's Müller muscles, causing them to contract and lift the eyelid
  3. Oxymetazoline hydrochloride (Upneeq®) SELF ADMINISTRATION - OPHTHALMIC SOLUTION. Indication for Prior Authorization: Indicated for the treatment of acquired blepharoptosis in adults. Coverage Criteria: Patient is 18 years of age and older, AND; Prescribed by or in consultation with an ophthalmologist or optometrist, AN
  4. al Demo Request Bloomberg Anywhere Remote Login Bloomberg Anywhere Login Bloomberg Customer Support Customer Suppor
  5. Upneeq™ (oxymetazoline hydrochloride ophthalmic solution 0.1%) is an ophthalmic drop which has acquired ptosis as an indication for its use. In response to concerns regarding the use of the drug by practitioners who may not be familiar with potentially serious neurological and orbital conditions associated with ptosis, the Academy, the American Society of Ophthalmic Plastic and.
  6. istration (FDA) for the treatment of acquired blepharoptosis or ptosis (droopy eyelids) in adults
  7. What Is Eyelid Ptosis? Eyelid ptosis (the 'p' is silent, friends), also known as blepharoptosis, is the medical term for a drooping eyelid. The condition can be caused by trauma, age, genetics, or various medical conditions, and there are two general classifications for ptosis: The solution, which includes oxymetazoline hydrochloride.

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  1. More recently, the efficacy and safety of an oxymetazoline 0.1% ophthalmic solution approved for the treatment of acquired ptosis (Upneeq TM, RVL Pharmaceuticals, Inc., Bridgewater, NJ, USA) has.
  2. When applied to the eyes, it targets a subset of adrenoreceptors in the Mueller's muscle and elevates the eyelid. According to Dr. Douglas, oxymetazoline has been studied for decades, and Upneeq itself was studied for about four years before getting FDA-approval in July 2020, making it the first medical treatment for acquired ptosis
  3. Jason Bacharach, MD, introduces the first and only FDA-approved pharmacologic treatment for acquired blepharoptosis, RVL-1201 (oxymetazoline hydrochloride ophthalmic solution), 0.1%, including its mechanism of action and clinical data
Patent Report: | US9867808 | Compositions and methods for

Upneeq contains oxymetazoline hydrochloride, a vasoconstrictor that causes the Müller's muscle—one of two muscles that open the eyelid—to contract, creating a lift that lasts about six. A therapy recommended to treat ptosis from administration of botulinum toxins A and B is the use of Iopidine™ (apraclonidine 0.5 %) eye drops . Apraclonidine is an α2-adrenergic agonist, which causes Müller muscles to contract, quickly elevating the upper eyelid 1-3 mm. Apraclonidine is used to treat glaucoma and Horner syndrome because of.

Noninvasive Ptosis Management - Review of Optometr

In July, Osmotica pharmaceuticals announced the FDA approval of Upneeq, a new nonsurgical treatment for acquired blepharoptosis, aka ptosis or drooping upper eyelid. Ptosis has to do with the actual position of the eyelid, says Dr. Rob Schwarcz, a board-certified oculoplastic surgeon in New York City.The result of the medical condition, he explains, is that the eyelash line sits lower. Ophthalmic formulation of oxymetazoline is used for treating acquired blepharoptosis or ptosis (droopy eye) in adults. It has also been used during nasal intubation and during ear, nose, and throat surgery to improve visualization of the airway and minimize postoperative bleeding It's simple: just enroll and use UPNEEQ™ (oxymetazoline hydrochloride ophthalmic solution) 0.1% once a day for the next 15 days. Once you enroll in the program and complete a brief survey, you can begin. Apply one drop of UPNEEQ in each ptotic eye, as directed, for the next 15 days

Ocular Ptosis and Its Differential Diagnosis - Modern

However, for the vast majority, ptosis is an age-associated dehiscence of the levator aponeurosis that makes patients feel and look old and affects their visual field. Upneeq (oxymetazoline 0.1%, Osmotica), recently FDA approved as a once-daily drop to treat acquired blepharoptosis, is an alpha-1 and partial alpha-2 adrenergic agonist capable. Objective To examine the efficacy and safety of oxymetazoline hydrochloride, 0.1%, ophthalmic solution (oxymetazoline, 0.1%) in participants with acquired ptosis (oxymetazoline hydrochloride ophthalmic solution, 0.1%) for the treatment of acquired blepharoptosis (ptosis). Ptosis is experienced by approximately 12% of adults over the age of 50 (Sridharan et al, 1995). It is a unilateral or bilateral abnormal drooping of the upper eyelid tha Upneeq ® is a safe and effective, first-in-class treatment for acquired ptosis and it demonstrated statistically significant improvements compared to placebo in both superior visual field and. Additionally, to treat the underlying ptosis, we recommended either surgical intervention or use of a compounded, preservative-free formulation of oxymetazoline. Medicamentosa may develop in patients who endure long-term exposure to certain topical medications or preservative agents

Data Highlight Efficacy, Safety of Potential Pharmacologic

Ptosis is an abnormal drooping of the upper eyelid margin with the eye in primary gaze 1. In addition to the characteristic asymmetric or sleepy appearance caused by ptosis, obstruction of the pupil by the upper eyelid can lead to superior visual field deficits. 2 Ptosis is a common eyelid disorder that is often associated with aging 3 4 5 The intent of this policy is to communicate the medical necessity criteria for Oxymetazoline (Upneeq™) as provided under the member's prescription drug benefit. Description: Blepharoptosis, or ptosis of the eyelid, refers to drooping of the upper eyelid that usually results from a congenital o Association of Oxymetazoline Hydrochloride, 0.1% Solution Administration with Visual Field in Acquired Ptosis A Pooled Analysis of 2 Randomized Clinical Trials. JAMA Ophthalmol. October 2020. Program Prior Authorization- Upneeq Change Control 12/2020 New progra In addition to the characteristic asymmetric or sleepy appearance caused by ptosis, obstruction of the pupil by the upper eyelid can lead to superior visual field deficits.2 Ptosis is a common eyelid disorder that is often associated with aging3 4 5.Upneeq contains oxymetazoline, a potent, direct-acting alpha-adrenergic receptor agonist. Expert-Led Dynamic Discussion: Update Your Approach to Acquired Ptosis with UPNEEQ ® (oxymetazoline hydrochloride ophthalmic solution), 0.1%

Osmotica Will Commercialize and Supply Non-Surgical Droopy

Abstract: Provided are pharmaceutical compositions, and methods of use of the compositions, for the non-surgical treatment of ptosis (eyelid droop). In one embodiment the composition includes oxymetazoline 0.1% formulated for topical administration to an eye. In one embodiment the composition includes a synergistic combination of oxymetazoline and phenylephrine, formulated for topical. ptosis of the affected eye as seen in Horner syndrome, a condition in which there is damage to the cervical sympathetic chain. Surgeries which involve repair of ptosis, or upper eyelid correction procedures, will usually Oxymetazoline is an alpha adrenoceptor agonist targeting a subset of adrenoreceptors in Mueller's muscle of the eyelid.

Miosis - Wikipedia

Oxymetazoline ophthalmic Uses, Side Effects & Warnings

Oxymetazoline alone causes no pupillary dilation (mydriasis), and a synergistic combination of oxymetazoline and phenylephrine induces no clinically significant mydriasis. In addition to providing desirable cosmetic effects, the compositions and methods of the invention can improve visual fields otherwise compromised by ptosis Osmotica Pharmaceuticals plc Receives FDA Approval for Upneeq™ (oxymetazoline hydrochloride ophthalmic solution), 0.1% for. July 9, 2020, 6:50 AM EDT also known as ptosis, or droopy eyelid. Ptosis can be treated in a number of ways. A new medical treatment has recently been approved by the FDA. It is called Upneeq. It is the same drug, oxymetazoline, that is used in Afrin. This drop elevates the lid 1-3 mm by stimulating the Muller's muscle. A picture is worth a thousand words Ptosis involves drooping of the upper eyelid over the eye. It can limit or completely block normal vision. The cause can be damaged nerves, which control eye muscles or looseness of skin of upper eyelids. The patent proposed two compositions - 0.1% oxymetazoline and oxymetazoline with phenylephrine

Upneeq (oxymetazoline hydrochloride ophthalmic solution), 0.1% is a novel, once-daily ophthalmic formulation of oxymetazoline, a direct-acting alpha adrenergic receptor agonist, which when administered to the eye, is believed to selectively target Müller's muscle and elevate the upper eyelid This medication is used to treat a certain eyelid condition (acquired blepharoptosis) that causes drooping upper eyelid(s). It belongs to a class of drugs known as alpha agonists. Oxymetazoline. Upneeq (oxymetazoline hydrochloride) ophthalmic solution is an alpha-adrenergic agonist used to treat acquired drooping upper eyelid (blepharoptosis) in adults. Side effects of Upneeq include punctate keratitis, eye redness, dry eye, blurred vision, instillation site pain, eye irritation, and headache Ptosis can sometimes be present at birth; this is known as congenital ptosis and is usually due to a defect in the upper eyelid muscle. However, more commonly it appears later in life, as an acquired ptosis. This can be the result of long-term contact lens wear, trauma or following othe The ptosis treatment market can be segmented based on treatment, service provider and region. Based on the treatment, the global ptosis treatment market is segmented as: Mechanical Treatment . Ptosis Crutches; Special Scleral Contact Lenses; Ptosis Taping; Non-mechanical Treatment . Botulinum Injection (BOTOX) Ulthera; Oxymetazoline.

Oxymetazoline eye drops offer promise for the treatment of

Osmotica Pharmaceuticals plc (Nasdaq: OSMT) (Osmotica or the Company), a fully integrated biopharmaceutical company, announced today that the U.S. Food and Drug Administration (FDA) has approved Upneeq (oxymetazoline hydrochloride ophthalmic solution), 0.1%, formerly known as RVL-1201, its novel treatment for acquired blepharoptosis, or ptosis, a condition characterized by the. Osmotica Pharmaceuticals plc Receives FDA Approval for Upneeq (oxymetazoline hydrochloride ophthalmic solution), 0.1% for Acquired Blepharoptosis (Droopy Eyelid) in Adults Posted on 07/09/2020 4

JAMA Ophthalmology Publishes Pooled Analysis of Data from

(PDF) Association of Oxymetazoline Hydrochloride, 0Orbital Cellulitis in a Child